Bryan and Jenny Masche are learning that being first-time parents to sextuplets is harder than they thought. Everything that parents of singletons go through extends to the sixth power in their world. Just washing the family dog, Luke, turns into a major ordeal when half a dozen 16-months-olds get in on the action. And when mom and dad take the six out to a restaurant, all eyes are on them. Though Jenny gained 80 pounds during her pregnancy, she's lost it all through baby wrangling and training for a marathon. Unfortunately, Bryan's 30-plus pounds of sympathy weight won't go away, so Jenny signs him up for a weight-loss program! And life is stressful enough just raising sextuplets, but after 18 months off, family finances finally force Jenny to head back to work in the ER as a physician assistant. Now the juggling act kicks into high gear!